Sridevi (Sri) Krishnan, M.Sc., PhD is a nutritional glycobiologist who studies how diet influences the development of age-related metabolic diseases. With a foundation in nutritional biology and recent expertise in glycobiology—the science of glycosylation, glycoproteins, and glycans—Sri works in a specialized field focused on how dietary and systemic glycans impact health, aging, and disease.

As part of the molecular working group in the CALERIE2 research network, Sri contributed to a pilot study showing that calorie restriction reduces both established and novel glycomic biomarkers of aging, including those found in plasma, IgG, and complement C3. Her current research explores how calorie restriction affects the glycome of alpha-1 acid glycoprotein (AGP), a highly glycosylated protein involved in immune response and metabolic regulation. AGP has recently been identified as a leptin receptor agonist, but the role of its glycosylation in modulating function remains unknown. This study is the first to evaluate AGP glycosylation before, during, and after a long-term dietary intervention.

Future research will expand this work to assess glycomic biomarkers of aging and longevity in obese populations, the full CALERIE2 cohort, and other U.S.-based studies.

Additional projects in Sri’s lab include developing oligosaccharide-based synbiotic interventions to improve blood glucose in individuals with type 2 diabetes, and creating GenAI-powered tools to make “Food as Medicine” strategies accessible to communities experiencing food and nutrition insecurity.