Publications - Calerie Network

Quadriceps mitochondrial DNA quantity, quality, and gene expression after 2 years of calorie restriction: exploratory results from the CALERIE trial

Date of Publication: 03/26/2026

Authored by: Jayanta K. Das, Yu Zhang, Leanne M. Redman, Corby K. Martin, Sai Krupa Das, Susan B. Racette, Allen Herbst, Nianjun Liu, David B. Allison, Debbie McKenzie, Judd M. Aiken, Steve Horvath, Julián Candia, Nirad Banskota, Luigi Ferrucci, William E. Kraus, Kim M. Huffman & Jonathan Wanagat

Pull Article: https://link.springer.com/article/10.1007/s11357-026-02167-1

Use of Machine Learning to Identify Determinants of Habitual-Preformed Water Intake

Date of Publication: 05/01/2026

Authored by: Emma J Stinson, Ethan Collins, Tomas Cabeza De Baca, Marci E Gluck, Manuel Dote-Montero, Susan B Racette, Stavros A Kavouras, Sai Krupa Das, Paolo Piaggi, Susanne Votruba, Ashley Hale, Douglas C Chang

Pull Article: https://www.sciencedirect.com/science/article/pii/S0022316626001240?via%3Dihub

The effect of leptin phenotype on weight change and energy expenditure responses to acute and prolonged energetic stressors

Date of Publication: 03/17/2025

Authored by: Falkanhain K, DeBaca TC, Stinson EJ, Ravussin E, Piaggi P, Krakiff J, Redman LM.

Pull Article: https://pubmed.ncbi.nlm.nih.gov/40094227/

Sustained caloric restriction potentiates insulin action by activating prostacyclin synthase

Date of Publication: 12/02/2024

Authored by: Merali C, Quinn C, Huffman KM, Pieper CF, Bogan JS, Barrero CA, Merali S

Pull Article: https://pubmed.ncbi.nlm.nih.gov/39420421/

Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis

Date of Publication: 06/03/2024

Authored by: Hastings WJ, Ye Q, Wolf SE, Ryan CP, Das SK, Huffman KM, Kobor MS, Kraus WE, MacIsaac JL, Martin CK, Racette SB, Redman LM, Belsky DW, Shalev I.

Pull Article: https://pubmed.ncbi.nlm.nih.gov/38504468/

Prediction of individual weight loss using supervised learning: findings from the CALERIETM 2 study

Date of Publication: 11/01/2024

Authored by: Glasbrenner C, Höchsmann C, Pieper CF, Wasserfurth P, Dorling JL, Martin CK, Redman LM, Koehler K.

Pull Article: https://pubmed.ncbi.nlm.nih.gov/39270937/

Intensive Versus Traditional Cardiac Rehabilitation: Mortality and Cardiovascular Outcomes in a 2016-2020 Retrospective Medicare Cohort

Date of Publication: 12/01/2023

Authored by: Husaini M, Deych E, Waken RJ, Sells B, Lai A, Racette SB, Rich MW, Joynt Maddox KE, Peterson LR.

Pull Article: https://pubmed.ncbi.nlm.nih.gov/38037867/

DNAmFitAge: biological age indicator incorporating physical fitness

Date of Publication: 02/22/2023

Authored by: McGreevy KM, Radak Z, Torma F, Jokai M, Lu AT, Belsky DW, Binder A, Marioni RE, Ferrucci L, Pośpiech E, Branicki W, Ossowski A, Sitek A, Spólnicka M, Raffield LM, Reiner AP, Cox S, Kobor M, Corcoran DL, Horvath S.

Pull Article: https://pubmed.ncbi.nlm.nih.gov/36812475/

Diet composition, adherence to calorie restriction, and cardiometabolic disease risk modification

Date of Publication: 10/23/2023

Authored by: Das SK, Silver RE, Senior A, Gilhooly CH, Bhapkar M, Le Couteur D

Pull Article: https://pubmed.ncbi.nlm.nih.gov/37873687/

Energy compensation and adiposity in humans

Date of Publication: 10/25/2021

Authored by: Careau V, Halsey LG, Pontzer H, Ainslie PN, Andersen LF, Anderson LJ, Arab L, Baddou I, Bedu-Addo K, Blaak EE, Blanc S, Bonomi AG, Bouten CVC, Buchowski MS, Butte NF, Camps SGJA, Close GL, Cooper JA, Das SK, Cooper R, Dugas LR, Eaton SD, Ekelund U, Entringer S, Forrester T, Fudge BW, Goris AH, Gurven M, Hambly C, El Hamdouchi A, Hoos MB, Hu S, Joonas N, Joosen AM, Katzmarzyk P, Kempen KP, Kimura M, Kraus WE, Kushner RF, Lambert EV, Leonard WR, Lessan N, Martin CK, Medin AC, Meijer EP, Morehen JC, Morton JP, Neuhouser ML, Nicklas TA, Ojiambo RM, Pietiläinen KH, Pitsiladis YP, Plange-Rhule J, Plasqui G, Prentice RL, Rabinovich RA, Racette SB, Raichlen DA, Ravussin E, Reilly JJ, Reynolds RM, Roberts SB, Schuit AJ, Sjödin AM, Stice E, Urlacher SS, Valenti G, Van Etten LM, Van Mil EA, Wells JCK, Wilson G, Wood BM, Yanovski J, Yoshida T, Zhang X, Murphy-Alford AJ, Loechl CU, Luke AH, Rood J, Sagayama H, Schoeller DA, Wong WW, Yamada Y, Speakman JR; IAEA DLW database group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/34453886/

Principal component-based clinical aging clocks identify signatures of healthy aging and targets for clinical intervention

Date of Publication: 06/19/2024

Authored by: Fong S, Pabis K, Latumalea D, Dugersuren N, Unfried M, Tolwinski N, Kennedy B, Gruber J.

Pull Article: https://pubmed.ncbi.nlm.nih.gov/38898237/

Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT

Date of Publication: 03/04/2024

Authored by: Bareja A, Lee DE, Ho T, Waitt G, McKay LH, Hannou SA, Orenduff MC, McGreevy KM, Binder A, Ryan CP, Soderblom EJ, Belsky DW, Ferrucci L, Das JK, Banskota N, Kraus VB, Huebner JL, Kraus WE, Huffman KM, Baht GS, Horvath S, Parmer RJ, Miles LA, White JP

Pull Article: https://pubmed.ncbi.nlm.nih.gov/38442019/

Calorie restriction reduces biomarkers of cellular senescence in humans

Date of Publication: 11/14/2023

Authored by: Aversa Z, White TA, Heeren AA, Hulshizer CA, Saul D, Zhang X, Molina AJA, Redman LM, Martin CK, Racette SB, Huffman KM, Bhapkar M, Khosla S, Das SK, Fielding RA, Atkinson EJ, LeBrasseur NK

Pull Article: https://pubmed.ncbi.nlm.nih.gov/37961856/

Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study

Date of Publication: 12/01/2023

Authored by: Das JK, Banskota N, Candia J, Griswold ME, Orenduff M, de Cabo R, Corcoran DL, Das SK, De S, Huffman KM, Kraus VB, Kraus WE, Martin CK, Racette SB, Redman LM, Schilling B, Belsky DW, Ferrucci L

Pull Article: https://pubmed.ncbi.nlm.nih.gov/37823711/

Body shape perception in men and women without obesity during caloric restriction: a secondary analysis from the CALERIE study

Date of Publication: 02/23/2023

Authored by: Jacobson MM, Gardner AM, Handley CE, Smith MW, Christensen WF, Hancock CR, Joseph PV, Larson MJ, Martin CK, LeCheminant JD

Pull Article: https://pmc.ncbi.nlm.nih.gov/articles/PMC9941245/

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

Date of Publication: 03/01/2023

Authored by: Waziry R, Ryan CP, Corcoran DL, Huffman KM, Kobor MS, Kothari M, Graf GH, Kraus VB, Kraus WE, Lin DTS, Pieper CF, Ramaker ME, Bhapkar M, Das SK, Ferrucci L, Hastings WJ, Kebbe M, Parker DC, Racette SB, Shalev I, Schilling B, Belsky DW

Pull Article: https://pubmed.ncbi.nlm.nih.gov/37118425/

Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis

Date of Publication: 12/29/2022

Authored by: Ramaker ME, Corcoran DL, Apsley AT, Kobor MS, Kraus VB, Kraus WE, Lin DTS, Orenduff MC, Pieper CF, Waziry R, Huffman KM, Belsky DW

Pull Article: https://pmc.ncbi.nlm.nih.gov/articles/PMC9799188/

No Effect of Calorie Restriction or Dietary Patterns on Spatial Working Memory During a 2-Year Intervention: A Secondary Analysis of the CALERIE Trial

Date of Publication: 03/06/2023

Authored by: Silver RE, Roberts SB, Kramer AF, Chui KKH, Das SK

Pull Article: https://pubmed.ncbi.nlm.nih.gov/36805108/

Modestly Increased Incidence of Ketosis in Caloric Restriction Does not Significantly Alter the Effects of Caloric Restriction

Date of Publication: 07/01/2022

Authored by: Ferguson BS, Sahoo P, McGrail E, Francois A, Stratton MS

Pull Article: https://pubmed.ncbi.nlm.nih.gov/35842755/

Nutritional quality of calorie restricted diets in the CALERIE™ 1 trial

Date of Publication: 08/01/2022

Authored by: Racette SB, Barry VG, Bales CW, McCrory MA, Obert KA, Gilhooly CH, Roberts SB, Martin CK, Champagne C, Das SK

Pull Article: https://pubmed.ncbi.nlm.nih.gov/35643360/

Associations between the timing of eating and weight-loss in calorically restricted healthy adults: Findings from the CALERIE study

Date of Publication: 08/01/2022

Authored by: Fleischer JG, Das SK, Bhapkar M, Manoogian ENC, Panda S

Pull Article: https://pubmed.ncbi.nlm.nih.gov/35598698/

Challenges in defining successful adherence to calorie restriction goals in humans: Results from CALERIE™ 2

Date of Publication: 06/01/2022

Authored by: Martin CK, Höchsmann C, Dorling JL, Bhapkar M, Pieper CF, Racette SB, Das SK, Redman LM, Kraus WE, Ravussin E; CALERIE™ Phase 2 Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/35240264/

The Complicated Relationship between Dieting, Dietary Restraint, Caloric Restriction, and Eating Disorders: Is a Shift in Public Health Messaging Warranted?

Date of Publication: 01/03/2022

Authored by: Stewart TM, Martin CK, Williamson DA

Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial

Date of Publication: 01/03/2022

Authored by: Huffman KM, Parker DC, Bhapkar M, Racette SB, Martin CK, Redman LM, Das SK, Connelly MA, Pieper CF, Orenduff M, Ross LM, Ramaker ME, Dorling JL, Rosen CJ, Shalaurova I, Otvos JD, Kraus VB, Kraus WE; CALERIE Investigators

Pull Article: https://pubmed.ncbi.nlm.nih.gov/35028547/

A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge

Date of Publication: 11/02/2021

Authored by: Kwon D, Belsky DW

Pull Article: https://pubmed.ncbi.nlm.nih.gov/34725754/

Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIE™ phase 2

Date of Publication: 09/20/2021

Authored by: Dorling JL, Belsky DW, Racette SB, Das SK, Ravussin E, Redman LM, Höchsmann C, Huffman KM, Kraus WE, Kobor MS, MacIsaac JL, Lin DTS, Corcoran DL, Martin CK

Pull Article: https://pmc.ncbi.nlm.nih.gov/articles/PMC8720865/

Effect of 2-year caloric restriction on organ and tissue size in nonobese 21- to 50-year-old adults in a randomized clinical trial: the CALERIE study

Date of Publication: 10/04/2021

Authored by: Shen W, Chen J, Zhou J, Martin CK, Ravussin E, Redman LM

Pull Article: https://pubmed.ncbi.nlm.nih.gov/34159359/

Beyond weight loss: current perspectives on the impact of calorie restriction on healthspan and lifespan

Date of Publication: 05/07/2021

Authored by: Kebbe M, Sparks JR, Flanagan EW, Redman LM

Pull Article: https://pmc.ncbi.nlm.nih.gov/articles/PMC9052419/

Calorie Restriction and Aging in Humans

Date of Publication: 09/23/2020

Authored by: Flanagan EW, Most J, Mey JT, Redman LM

Pull Article: https://pubmed.ncbi.nlm.nih.gov/32559388/

Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2

Date of Publication: 01/01/2021

Authored by: Dorling JL, van Vliet S, Huffman KM, Kraus WE, Bhapkar M, Pieper CF, Stewart T, Das SK, Racette SB, Roberts SB, Ravussin E, Redman LM, Martin CK; CALERIE Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/32940695/

Molecular correlates of MRS-based 31 phosphocreatine muscle resynthesis rate in healthy adults

Date of Publication: 09/01/2020

Authored by: Darpolor MM, Singh M, Covington J, Hanet S, Ravussin E, Carmichael OT

Pull Article: https://pmc.ncbi.nlm.nih.gov/articles/PMC8491428/

Effect of 2 years of calorie restriction on liver biomarkers: results from the CALERIE phase 2 randomized controlled trial

Date of Publication: 08/04/2020

Authored by: Dorling JL, Ravussin E, Redman LM, Bhapkar M, Huffman KM, Racette SB, Das SK, Apolzan JW, Kraus WE, Höchsmann C, Martin CK; CALERIE Phase 2 Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/32803412/

Caloric restriction, resting metabolic rate and cognitive performance in Non-obese adults: A post-hoc analysis from CALERIE study

Date of Publication: 05/25/2020

Authored by: Grigolon RB, Brietzke E, Trevizol AP, McIntyre RS, Mansur RB

Pull Article: https://pubmed.ncbi.nlm.nih.gov/32485641/

Impact of calorie restriction on energy metabolism in humans

Date of Publication: 02/11/2020

Authored by: Most J, Redman LM

Pull Article: https://pubmed.ncbi.nlm.nih.gov/32057825/

Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

Date of Publication: 05/05/2020

Authored by: Belsky DW, Caspi A, Arseneault L, Baccarelli A, Corcoran DL, Gao X, Hannon E, Harrington HL, Rasmussen LJ, Houts R, Huffman K, Kraus WE, Kwon D, Mill J, Pieper CF, Prinz JA, Poulton R, Schwartz J, Sugden K, Vokonas P, Williams BS, Moffitt TE

Pull Article: https://pubmed.ncbi.nlm.nih.gov/32367804/

Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial

Date of Publication: 03/06/2020

Authored by: Dorling JL, Das SK, Racette SB, Apolzan JW, Zhang D, Pieper CF, Martin CK; CALERIE Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/32144378/

Does exclusion of extreme reporters of energy intake (the “Goldberg cutoffs”) reliably reduce or eliminate bias in nutrition studies? Analysis with illustrative associations of energy intake with health outcomes

Date of Publication: 11/01/2019

Authored by: Ejima K, Brown AW, Schoeller DA, Heymsfield SB, Nelson EJ, Allison DB

Pull Article: https://pubmed.ncbi.nlm.nih.gov/31504097/

Change in self-efficacy, eating behaviors and food cravings during two years of calorie restriction in humans without obesity

Date of Publication: 12/01/2019

Authored by: Dorling JL, Bhapkar M, Das SK, Racette SB, Apolzan JW, Fearnbach SN, Redman LM, Myers CA, Stewart TM, Martin CK; CALERIE Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/31398376/

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial

Date of Publication: 09/02/2019

Authored by: Kraus WE, Bhapkar M, Huffman KM, Pieper CF, Krupa Das S, Redman LM, Villareal DT, Rochon J, Roberts SB, Ravussin E, Holloszy JO, Fontana L; CALERIE Investigators

Pull Article: https://pubmed.ncbi.nlm.nih.gov/31303390/

The effect of caloric restriction on working memory in healthy non-obese adults

Date of Publication: 02/03/2020

Authored by: Leclerc E, Trevizol AP, Grigolon RB, Subramaniapillai M, McIntyre RS, Brietzke E, Mansur RB

Pull Article: https://pubmed.ncbi.nlm.nih.gov/30968820/

Peripheral interleukin-6 levels and working memory in non-obese adults: A post-hoc analysis from the CALERIE study

Date of Publication: 02/04/2019

Authored by: Trevizol AP, Brietzke E, Grigolon RB, Subramaniapillai M, McIntyre RS, Mansur RB

Pull Article: https://pubmed.ncbi.nlm.nih.gov/30273821/

Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging

Date of Publication: 04/03/2018

Authored by: Redman LM, Smith SR, Burton JH, Martin CK, Il'yasova D, Ravussin E.

Pull Article: https://pubmed.ncbi.nlm.nih.gov/29576535/

Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial

Date of Publication: 02/09/2018

Authored by: Il'yasova D, Fontana L, Bhapkar M, Pieper CF, Spasojevic I, Redman LM, Das SK, Huffman KM, Kraus WE; CALERIE Study Investigators

Pull Article: https://pubmed.ncbi.nlm.nih.gov/29424490/

Significant improvement in cardiometabolic health in healthy nonobese individuals during caloric restriction-induced weight loss and weight loss maintenance

Date of Publication: 04/01/2018

Authored by: Most J, Gilmore LA, Smith SR, Han H, Ravussin E, Redman LM

Pull Article: https://pubmed.ncbi.nlm.nih.gov/29351490/

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

Date of Publication: 07/04/2016

Authored by: Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, Gupta AK, Villareal DT, Bhapkar M, Huang M, Fuss PJ, Roberts SB, Holloszy JO, Fontana L

Pull Article: https://pubmed.ncbi.nlm.nih.gov/27410480/

Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength

Date of Publication: 11/06/2017

Authored by: Racette SB, Rochon J, Uhrich ML, Villareal DT, DAS SK, Fontana L, Bhapkar M, Martin CK, Redman LM, Fuss PJ, Roberts SB, Kraus WE

Pull Article: https://pubmed.ncbi.nlm.nih.gov/29045325/

Nutrition modulation of human aging: The calorie restriction paradigm

Date of Publication: 11/05/2017

Authored by: Das SK, Balasubramanian P, Weerasekara YK

Pull Article: https://pubmed.ncbi.nlm.nih.gov/28412520/

Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis

Date of Publication: 12/12/2017

Authored by: Belsky DW, Huffman KM, Pieper CF, Shalev I, Kraus WE

Pull Article: https://pubmed.ncbi.nlm.nih.gov/28531269/

Safety of two-year caloric restriction in non-obese healthy individuals

Date of Publication: 04/12/2016

Authored by: Romashkan SV, Das SK, Villareal DT, Ravussin E, Redman LM, Rochon J, Bhapkar M, Kraus WE; CALERIE Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/26992237/

Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans

Date of Publication: 02/22/2017

Authored by: Das SK, Roberts SB, Bhapkar MV, Villareal DT, Fontana L, Martin CK, Racette SB, Fuss PJ, Kraus WE, Wong WW, Saltzman E, Pieper CF, Fielding RA, Schwartz AV, Ravussin E, Redman LM; CALERIE-2 Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/28228420/

Persistence of weight loss and acquired behaviors 2 y after stopping a 2-y calorie restriction intervention

Date of Publication: 03/08/2017

Authored by: Marlatt KL, Redman LM, Burton JH, Martin CK, Ravussin E

Pull Article: https://pubmed.ncbi.nlm.nih.gov/28275127/

Application of the Marginal Structural Model to Account for Suboptimal Adherence in a Randomized Controlled Trial

Date of Publication: 12/15/2016

Authored by: Rochon J, Bhapkar M, Pieper CF, Kraus WE

Pull Article: https://pmc.ncbi.nlm.nih.gov/articles/PMC5124349/

Six-month Calorie Restriction in Overweight Individuals Elicits Transcriptomic Response in Subcutaneous Adipose Tissue That is Distinct From Effects of Energy Deficit

Date of Publication: 10/20/2015

Authored by: Lam YY, Ghosh S, Civitarese AE, Ravussin E

Pull Article: https://pubmed.ncbi.nlm.nih.gov/26486851/

Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial

Date of Publication: 06/01/2016

Authored by: Martin CK, Bhapkar M, Pittas AG, Pieper CF, Das SK, Williamson DA, Scott T, Redman LM, Stein R, Gilhooly CH, Stewart T, Robinson L, Roberts SB; Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) Phase 2 Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/27136347/

Effects of 12 Months of Caloric Restriction on Muscle Mitochondrial Function in Healthy Individuals

Date of Publication: 01/01/2017

Authored by: Sparks LM, Redman LM, Conley KE, Harper ME, Yi F, Hodges A, Eroshkin A, Costford SR, Gabriel ME, Shook C, Cornnell HH, Ravussin E, Smith SR

Pull Article: https://pubmed.ncbi.nlm.nih.gov/27778643/

Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial

Date of Publication: 10/06/2015

Authored by: Fontana L, Villareal DT, Das SK, Smith SR, Meydani SN, Pittas AG, Klein S, Bhapkar M, Rochon J, Ravussin E, Holloszy JO; CALERIE Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/26443692/

Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial

Date of Publication: 01/04/2016

Authored by: Villareal DT, Fontana L, Das SK, Redman L, Smith SR, Saltzman E, Bales C, Rochon J, Pieper C, Huang M, Lewis M, Schwartz AV; CALERIE Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/26332798/

Decline in Bone Mass During Weight Loss: A Cause for Concern?

Date of Publication: 01/04/2016

Authored by: Schafer AL

Pull Article: https://pubmed.ncbi.nlm.nih.gov/26595270/

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity

Date of Publication: 07/17/2015

Authored by: Ravussin E, Redman LM, Rochon J, Das SK, Fontana L, Kraus WE, Romashkan S, Williamson DA, Meydani SN, Villareal DT, Smith SR, Stein RI, Scott TM, Stewart TM, Saltzman E, Klein S, Bhapkar M, Martin CK, Gilhooly CH, Holloszy JO, Hadley EC, Roberts SB; CALERIE Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/26187233/

Two-Year Trial of Human Caloric Restriction

Date of Publication: 07/17/2015

Authored by: Di Francesco A, de Cabo R

Pull Article: https://pubmed.ncbi.nlm.nih.gov/26187232/

Effect of 6-month caloric restriction on Cu bound to ceruloplasmin in adult overweight subjects

Date of Publication: 05/06/2015

Authored by: Piacenza F, Malavolta M, Basso A, Costarelli L, Giacconi R, Ravussin E, Redman LM, Mocchegiani E

Pull Article: https://pubmed.ncbi.nlm.nih.gov/26001545/

Calorie Restriction and Matched Weight Loss From Exercise: Independent and Additive Effects on Glucoregulation and the Incretin System in Overweight Women and Men

Date of Publication: 04/15/2015

Authored by: Weiss EP, Albert SG, Reeds DN, Kress KS, Ezekiel UR, McDaniel JL, Patterson BW, Klein S, Villareal DT

Pull Article: https://pubmed.ncbi.nlm.nih.gov/25877812/

Effect of dietary adherence on the body weight plateau: a mathematical model incorporating intermittent compliance with energy intake prescription

Date of Publication: 07/30/2014

Authored by: Thomas DM, Martin CK, Redman LM, Heymsfield SB, Lettieri S, Levine JA, Bouchard C, Schoeller DA

Pull Article: https://pubmed.ncbi.nlm.nih.gov/25080458/

The doubly labeled water method produces highly reproducible longitudinal results in nutrition studies

Date of Publication: 02/12/2014

Authored by: Wong WW, Roberts SB, Racette SB, Das SK, Redman LM, Rochon J, Bhapkar MV, Clarke LL, Kraus WE

Pull Article: https://pubmed.ncbi.nlm.nih.gov/24523488/

No effect of caloric restriction on salivary cortisol levels in overweight men and women

Date of Publication: 10/24/2013

Authored by: Tam CS, Frost EA, Xie W, Rood J, Ravussin E, Redman LM; Pennington CALERIE Team

Pull Article: https://pubmed.ncbi.nlm.nih.gov/24268369/

Energy requirements in nonobese men and women: results from CALERIE

Date of Publication: 11/13/2013

Authored by: Redman LM, Kraus WE, Bhapkar M, Das SK, Racette SB, Martin CK, Fontana L, Wong WW, Roberts SB, Ravussin E; CALERIE Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/24257721/

Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE Phase 2) screening and recruitment: methods and results

Date of Publication: 09/05/2012

Authored by: Stewart TM, Bhapkar M, Das S, Galan K, Martin CK, McAdams L, Pieper C, Redman L, Roberts S, Stein RI, Rochon J, Williamson DA; CALERIE Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/22981898/

Energy content of weight loss: kinetic features during voluntary caloric restriction

Date of Publication: 01/16/2012

Authored by: Heymsfield SB, Thomas D, Martin CK, Redman LM, Strauss B, Bosy-Westphal A, Müller MJ, Shen W, Martin Nguyen A

Pull Article: https://pubmed.ncbi.nlm.nih.gov/22257646/

Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial

Date of Publication: 04/16/2012

Authored by: Huffman KM, Redman LM, Landerman LR, Pieper CF, Stevens RD, Muehlbauer MJ, Wenner BR, Bain JR, Kraus VB, Newgard CB, Ravussin E, Kraus WE

Pull Article: https://pubmed.ncbi.nlm.nih.gov/22523532/

The CALERIE Genomic Data Resource

Date of Publication: 02/05/2025

Authored by: Ryan CP, Corcoran DL, Banskota N, Eckstein Indik C, Floratos A, Friedman R, Kobor MS, Kraus VB, Kraus WE, MacIsaac JL, Orenduff MC, Pieper CF, White JP, Ferrucci L, Horvath S, Huffman KM, Belsky DW

Pull Article: https://pubmed.ncbi.nlm.nih.gov/39672986/

Approaches for quantifying energy intake and %calorie restriction during calorie restriction interventions in humans: the multicenter CALERIE study

Date of Publication: 02/15/2012

Authored by: Racette SB, Das SK, Bhapkar M, Hadley EC, Roberts SB, Ravussin E, Pieper C, DeLany JP, Kraus WE, Rochon J, Redman LM; CALERIE Study Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/22127229/

Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction

Date of Publication: 01/02/2012

Authored by: Murphy JC, McDaniel JL, Mora K, Villareal DT, Fontana L, Weiss EP

Pull Article: https://pubmed.ncbi.nlm.nih.gov/22016371/

The CALERIE Study: design and methods of an innovative 25% caloric restriction intervention

Date of Publication: 11/25/2011

Authored by: Rickman AD, Williamson DA, Martin CK, Gilhooly CH, Stein RI, Bales CW, Roberts S, Das SK

Pull Article: https://pubmed.ncbi.nlm.nih.gov/21767664/

A 2-year calorie restriction intervention may reduce glycomic biological age biomarkers – a pilot study

Date of Publication: 08/01/2025

Authored by: Pribić T, Das JK, Đerek L, Belsky DW, Orenduff M, Huffman KM, Kraus WE, Deriš H, Šimunović J, Štambuk T, Hodžić AF, Kraus VB, Das SK, Racette SB, Banskota N, Ferruci L, Pieper C, Lewis NE, Lauc G, Krishnan S

Pull Article: https://duke.is/n/ab4z

The effect of leptin phenotype on weight change and energy expenditure responses to acute and prolonged energetic stressors

Date of Publication: 03/17/2025

Authored by: Falkanhain K, DeBaca TC, Stinson EJ, Ravussin E, Piaggi P, Krakiff J, Redman LM.

Pull Article: https://pubmed.ncbi.nlm.nih.gov/40094227/

Effect of caloric restriction on organ size and its contribution to metabolic adaptation: an ancillary analysis of CALERIE 2

Date of Publication: 08/19/2025

Authored by: Falkenhain, K., Redman, L.M., Chen, W. et al.

Pull Article: https://rdcu.be/eCz8F

The CALERIE Study: design and methods of an innovative 25% caloric restriction intervention

Date of Publication: 11/07/2011

Authored by: Rickman AD, Williamson DA, Martin CK, Gilhooly CH, Stein RI, Bales CW, Roberts S, Das SK

Pull Article: https://pubmed.ncbi.nlm.nih.gov/21767664/

The fall in leptin concentration is a major determinant of the metabolic adaptation induced by caloric restriction independently of the changes in leptin circadian rhythms

Date of Publication: 09/05/2011

Authored by: Lecoultre V, Ravussin E, Redman LM

Pull Article: https://pubmed.ncbi.nlm.nih.gov/21778216/

Dietary adherence to long-term controlled feeding in a calorie-restriction study in overweight men and women

Date of Publication: 06/06/2011

Authored by: Moreira EA, Most M, Howard J, Ravussin E

Pull Article: https://pubmed.ncbi.nlm.nih.gov/21586416/

The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: results from the CALERIE Trial of Human Caloric Restriction

Date of Publication: 06/06/2011

Authored by: Meydani M, Das S, Band M, Epstein S, Roberts S

Pull Article: https://pubmed.ncbi.nlm.nih.gov/21623467/

Development of adherence metrics for caloric restriction interventions

Date of Publication: 04/04/2011

Authored by: Pieper C, Redman L, Racette S, Roberts S, Bhapkar M, Rochon J, Martin C, Kraus W, Das S, Williamson D, Ravussin E

Pull Article: https://pubmed.ncbi.nlm.nih.gov/21385788/

Effect of calorie restriction on the free-living physical activity levels of nonobese humans: results of three randomized trials

Date of Publication: 04/04/2011

Authored by: Martin CK, Das SK, Lindblad L, Racette SB, McCrory MA, Weiss EP, Delany JP, Kraus WE; CALERIE Study Team

Pull Article: https://pubmed.ncbi.nlm.nih.gov/21292847/

Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women

Date of Publication: 02/07/2011

Authored by: Redman LM, Huffman KM, Landerman LR, Pieper CF, Bain JR, Muehlbauer MJ, Stevens RD, Wenner BR, Kraus VB, Newgard CB, Kraus WE, Ravussin E

Pull Article: https://pubmed.ncbi.nlm.nih.gov/21123443/

Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy

Date of Publication: 01/03/2011

Authored by: Rochon J, Bales CW, Ravussin E, Redman LM, Holloszy JO, Racette SB, Roberts SB, Das SK, Romashkan S, Galan KM, Hadley EC, Kraus WE; CALERIE Study Group.

Pull Article: https://pubmed.ncbi.nlm.nih.gov/20923909/

Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production

Date of Publication: 03/01/2010

Authored by: Fontana L, Klein S, Holloszy JO

Pull Article: https://pubmed.ncbi.nlm.nih.gov/19904628/

The effect of caloric restriction interventions on growth hormone secretion in nonobese men and women

Date of Publication: 02/01/2010

Authored by: Redman LM, Veldhuis JD, Rood J, Smith SR, Williamson D, Ravussin E; Pennington CALERIE Team

Pull Article: https://pubmed.ncbi.nlm.nih.gov/19878147/

Impact of 6-month caloric restriction on autonomic nervous system activity in healthy, overweight, individuals

Date of Publication: 02/01/2010

Authored by: de Jonge L, Moreira EA, Martin CK, Ravussin E; Pennington CALERIE Team

Pull Article: https://pubmed.ncbi.nlm.nih.gov/19910943/

Caloric restriction with or without exercise: the fitness versus fatness debate

Date of Publication: 01/04/2010

Authored by: Larson-Meyer DE, Redman L, Heilbronn LK, Martin CK, Ravussin E

Pull Article: https://pubmed.ncbi.nlm.nih.gov/20010118/

Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss

Date of Publication: 02/09/2009

Authored by: Redman LM, Heilbronn LK, Martin CK, de Jonge L, Williamson DA, Delany JP, Ravussin E; Pennington CALERIE Team

Pull Article: https://pubmed.ncbi.nlm.nih.gov/19198647/

Effect of calorie restriction on subjective ratings of appetite

Date of Publication: 04/06/2009

Authored by: Anton SD, Han H, York E, Martin CK, Ravussin E, Williamson DA

Pull Article: https://pubmed.ncbi.nlm.nih.gov/19302119/

Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals

Date of Publication: 03/02/2009

Authored by: Lefevre M, Redman LM, Heilbronn LK, Smith JV, Martin CK, Rood JC, Greenway FL, Williamson DA, Smith SR, Ravussin E; Pennington CALERIE team

Pull Article: https://pubmed.ncbi.nlm.nih.gov/18602635/

Use of cereal fiber to facilitate adherence to a human caloric restriction program

Date of Publication: 12/01/2008

Authored by: Gilhooly CH, Das SK, Golden JK, McCrory MA, Rochon J, DeLany JP, Freed AM, Fuss PJ, Dallal GE, Saltzman E, Roberts SB

Pull Article: https://pubmed.ncbi.nlm.nih.gov/19179834/

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans

Date of Publication: 10/06/2008

Authored by: Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO

Pull Article: https://pubmed.ncbi.nlm.nih.gov/18843793/

Calorie restriction and bone health in young, overweight individuals

Date of Publication: 09/22/2008

Authored by: Redman LM, Rood J, Anton SD, Champagne C, Smith SR, Ravussin E; Pennington Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) Research Team

Pull Article: https://pubmed.ncbi.nlm.nih.gov/18809812/

In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets

Date of Publication: 09/15/2008

Authored by: Allard JS, Heilbronn LK, Smith C, Hunt ND, Ingram DK, Ravussin E; Pennington CALERIE Team; de Cabo R

Pull Article: https://pubmed.ncbi.nlm.nih.gov/18791640/

Effect of caloric restriction in non-obese humans on physiological, psychological and behavioral outcomes

Date of Publication: 08/06/2008

Authored by: Redman LM, Martin CK, Williamson DA, Ravussin E

Pull Article: https://pubmed.ncbi.nlm.nih.gov/18502453/

Influence of weekend lifestyle patterns on body weight

Date of Publication: 08/04/2008

Authored by: Racette SB, Weiss EP, Schechtman KB, Steger-May K, Villareal DT, Obert KA, Holloszy JO

Pull Article: https://pubmed.ncbi.nlm.nih.gov/18551108/

Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function

Date of Publication: 06/02/2008

Authored by: Larson-Meyer DE, Newcomer BR, Heilbronn LK, Volaufova J, Smith SR, Alfonso AJ, Lefevre M, Rood JC, Williamson DA, Ravussin E; Pennington CALERIE Team

Pull Article: https://pubmed.ncbi.nlm.nih.gov/18421281/

The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function

Date of Publication: 03/03/2008

Authored by: Riordan MM, Weiss EP, Meyer TE, Ehsani AA, Racette SB, Villareal DT, Fontana L, Holloszy JO, Kovács SJ

Pull Article: https://pubmed.ncbi.nlm.nih.gov/18162561/

Psychosocial and behavioral pre-treatment predictors of weight loss outcomes

Date of Publication: 03/03/2008

Authored by: Anton SD, Martin CK, Redman L, York-Crowe E, Heilbronn LK, Han H, Williamson DA, Ravussin E

Pull Article: https://pubmed.ncbi.nlm.nih.gov/18319635/

Effect of calorie restriction on resting metabolic rate and spontaneous physical activity

Date of Publication: 12/03/2007

Authored by: Martin CK, Heilbronn LK, de Jonge L, DeLany JP, Volaufova J, Anton SD, Redman LM, Smith SR, Ravussin E

Pull Article: https://pubmed.ncbi.nlm.nih.gov/18198305/

Long-term effects of 2 energy-restricted diets differing in glycemic load on dietary adherence, body composition, and metabolism in CALERIE: a 1-y randomized controlled trial

Date of Publication: 04/02/2007

Authored by: Das SK, Gilhooly CH, Golden JK, Pittas AG, Fuss PJ, Cheatham RA, Tyler S, Tsay M, McCrory MA, Lichtenstein AH, Dallal GE, Dutta C, Bhapkar MV, Delany JP, Saltzman E, Roberts SB

Pull Article: https://pubmed.ncbi.nlm.nih.gov/17413101/

Examination of cognitive function during six months of calorie restriction: results of a randomized controlled trial

Date of Publication: 06/01/2007

Authored by: Martin CK, Anton SD, Han H, York-Crowe E, Redman LM, Ravussin E, Williamson DA

Pull Article: https://pubmed.ncbi.nlm.nih.gov/17518698/

The effect of leptin phenotype on weight change and energy expenditure responses to acute and prolonged energetic stressors

Date of Publication: 03/17/2025

Authored by: Falkanhain K, DeBaca TC, Stinson EJ, Ravussin E, Piaggi P, Krakiff J, Redman LM

Pull Article: https://pubmed.ncbi.nlm.nih.gov/40094227/

Is caloric restriction associated with development of eating-disorder symptoms? Results from the CALERIE trial

Date of Publication: 01/01/2008

Authored by: Williamson DA, Martin CK, Anton SD, York-Crowe E, Han H, Redman L, Ravussin E; Pennington CALERIE Team

Pull Article: https://pubmed.ncbi.nlm.nih.gov/18248104/

Empirical evaluation of the ability to learn a calorie counting system and estimate portion size and food intake

Date of Publication: 08/01/2007

Authored by: Martin CK, Anton SD, York-Crowe E, Heilbronn LK, VanSkiver C, Redman LM, Greenway FL, Ravussin E, Williamson DA; Pennington CALERIE Team

Pull Article: https://pubmed.ncbi.nlm.nih.gov/17397559/

Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial

Date of Publication: 07/02/2007

Authored by: Fontana L, Villareal DT, Weiss EP, Racette SB, Steger-May K, Klein S, Holloszy JO; Washington University School of Medicine CALERIE Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/17389710/

Improvements in body composition, glucose tolerance, and insulin action induced by increasing energy expenditure or decreasing energy intake

Date of Publication: 04/02/2007

Authored by: Weiss EP, Holloszy JO

Pull Article: https://pubmed.ncbi.nlm.nih.gov/17374683/

Measurement of dietary restraint: validity tests of four questionnaires

Date of Publication: 03/01/2007

Authored by: Williamson DA, Martin CK, York-Crowe E, Anton SD, Redman LM, Han H, Ravussin E

Pull Article: https://pubmed.ncbi.nlm.nih.gov/17101191/

Effect of calorie restriction with or without exercise on body composition and fat distribution

Date of Publication: 03/01/2007

Authored by: Redman LM, Heilbronn LK, Martin CK, Alfonso A, Smith SR, Ravussin E; Pennington CALERIE Team

Pull Article: https://pubmed.ncbi.nlm.nih.gov/17200169/

Calorie restriction increases muscle mitochondrial biogenesis in healthy humans

Date of Publication: 03/01/2007

Authored by: Civitarese AE, Carling S, Heilbronn LK, Hulver MH, Ukropcova B, Deutsch WA, Smith SR, Ravussin E; CALERIE Pennington Team

Pull Article: https://pubmed.ncbi.nlm.nih.gov/17341128/

Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss

Date of Publication: 02/01/2007

Authored by: Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Ehsani AA, Holloszy JO; Washington University School of Medicine CALERIE Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/17095635/

Validation study of energy expenditure and intake during calorie restriction using doubly labeled water and changes in body composition

Date of Publication: 01/01/2007

Authored by: de Jonge L, DeLany JP, Nguyen T, Howard J, Hadley EC, Redman LM, Ravussin E

Pull Article: https://pubmed.ncbi.nlm.nih.gov/17209180/

Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial

The effects of the dietary glycemic load on type 2 diabetes risk factors during weight loss

Date of Publication: 12/01/2006

Authored by: Pittas AG, Roberts SB, Das SK, Gilhooly CH, Saltzman E, Golden J, Stark PC, Greenberg AS

Pull Article: https://pubmed.ncbi.nlm.nih.gov/17189547/

Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial

Date of Publication: 12/11/2006

Authored by: Villareal DT, Fontana L, Weiss EP, Racette SB, Steger-May K, Schechtman KB, Klein S, Holloszy JO

Pull Article: https://pubmed.ncbi.nlm.nih.gov/17159017/

Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial

Date of Publication: 11/01/2006

Authored by: Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Holloszy JO; Washington University School of Medicine CALERIE Group

Pull Article: https://pubmed.ncbi.nlm.nih.gov/17093155/

One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue

Date of Publication: 09/01/2006

Authored by: Racette SB, Weiss EP, Villareal DT, Arif H, Steger-May K, Schechtman KB, Fontana L, Klein S, Holloszy JO

Pull Article: https://pubmed.ncbi.nlm.nih.gov/16960025/

Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects

Date of Publication: 06/01/2006

Authored by: Larson-Meyer DE, Heilbronn LK, Redman LM, Newcomer BR, Frisard MI, Anton S, Smith SR, Alfonso A, Ravussin E

Pull Article: https://pubmed.ncbi.nlm.nih.gov/16732018/

Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial

Date of Publication: 04/05/2006

Authored by: Heilbronn LK, de Jonge L, Frisard MI, DeLany JP, Larson-Meyer DE, Rood J, Nguyen T, Martin CK, Volaufova J, Most MM, Greenway FL, Smith SR, Deutsch WA, Williamson DA, Ravussin E; Pennington CALERIE Team.

Pull Article: https://pubmed.ncbi.nlm.nih.gov/16595757/

A low-glycemic load diet facilitates greater weight loss in overweight adults with high insulin secretion but not in overweight adults with low insulin secretion in the CALERIE Trial

Date of Publication: 12/01/2005

Authored by: Pittas AG, Das SK, Hajduk CL, Golden J, Saltzman E, Stark PC, Greenberg AS, Roberts SB

Pull Article: https://diabetesjournals.org/care/article/28/12/2939/22838/A-Low-Glycemic-Load-Diet-Facilitates-Greater